A collaboration between researchers from the Universidad Austral de Chile (UACh), Universidad Andrés Bello (UNAB), the Interdisciplinary Center for Aquaculture Research (INCAR), and the Animal Health Research Center (CISA) in Spain has determined that the Infectious Pancreatic Necrosis Virus (IPNV) is capable of altering the expression of key genes in the immune system of rainbow trout through epigenetic mechanisms. The study titled “Epigenetic reprogramming around IFN1 and IFNy2 promoters in rainbow trout cells inoculated with infectious pancreatic necrosis virus (IPNV)”, authored by René Manríquez, Moisés Sandoval, Carlos Loncoman, Carolina Tafalla, Ruben Avendaño-Herrera, and Juan Guillermo Cárcamo, would be the first to demonstrate the effect of epigenetic reprogramming after IPNV infection in salmonid cells. “This demonstrates that the level of promoter methylation/demethylation and changes in histone code associated with the promoters may play a role in modulating the immune response induced by the virus,” explain the researchers.
For more information, please read the manuscript published in Fish & Shellfish Immunology in the following link.
